Extracellular Vesicles in Angiogenesis

During the past decade, extracellular vesicles (EVs), which include apoptotic bodies, microvesicles, and exosomes, have emerged as important players in cell-to-cell communication in normal physiology and pathological conditions. EVs encapsulate and convey various bioactive molecules that are further transmitted to neighboring or more distant cells, where they induce various signaling cascades. The message delivered to the target cells is dependent on EV composition, which, in turn, is determined by the cell of origin and the surrounding microenvironment during EV biogenesis. Among their multifaceted role in the modulation of biological responses, the involvement of EVs in vascular development, growth, and…

• AN
  Agence Nationale de la Recherche

  Awards: ANR-11-IDEX-0001, ANR-11-IDEX, 11-IDEX-0001-02, IDEX-0001-02, ANR-11-IDEX-0001-02
• IN
  Institut National de la Santé et de la Recherche Médicale

  Award: ANR-11-IDEX-0001-02