Chalcone: A Privileged Structure in Medicinal Chemistry
Second Military Medical University · Ningxia Medical University · +1 more institution
Abstract
Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of…
Citation impact
- FWCI
- 46.15
- Percentile
- 100%
- References
- 455
Authors
6Topics & keywords
- Chalcone
- Chemistry
- Drug discovery
- Combinatorial chemistry
- Nanotechnology
- Computational biology
- Organic chemistry
- Biochemistry