reviewVirusesMay 10, 2017GOLD OA

African Swine Fever Virus: A Review

IGInmaculada GalindoCACovadonga Alonso

Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria

PubMed
Indexed incrossrefdoajpubmed

Abstract

African swine fever (ASF) is a highly contagious viral disease of swine which causes high mortality, approaching 100%, in domestic pigs. ASF is caused by a large, double stranded DNA virus, ASF virus (ASFV), which replicates predominantly in the cytoplasm of macrophages and is the only member of the Asfarviridae family, genus Asfivirus. The natural hosts of this virus include wild suids and arthropod vectors of the Ornithodoros genus. The infection of ASFV in its reservoir hosts is usually asymptomatic and develops a persistent infection. In contrast, infection of domestic pigs leads to a lethal hemorrhagic fever for which there is no effective vaccine. Identification of ASFV genes involved in virulence and…

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Topics & keywords

Topics
Keywords
  • African swine fever virus
  • Virology
  • Biology
  • Virus
  • DNA virus
  • Virulence
  • Viral replication
  • Host (biology)
UN Sustainable Development Goals
  • Good health and well-being
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