The Fungal Cell Wall: Structure, Biosynthesis, and Function

The molecular composition of the cell wall is critical for the biology and ecology of each fungal species. Fungal walls are composed of matrix components that are embedded and linked to scaffolds of fibrous load-bearing polysaccharides. Most of the major cell wall components of fungal pathogens are not represented in humans, other mammals, or plants, and therefore the immune systems of animals and plants have evolved to recognize many of the conserved elements of fungal walls. For similar reasons the enzymes that assemble fungal cell wall components are excellent targets for antifungal chemotherapies and fungicides. However, for fungal pathogens, the cell wall is often disguised since key signature molecules…

• WT
  Wellcome Trust
• AN
  Agence Nationale de la Recherche
• MR
  Medical Research Council Centre for Medical Mycology
• MR
  Medical Research Council

  Award: MR/N006364/1