HDOCK: a web server for protein–protein and protein–DNA/RNA docking based on a hybrid strategy

Protein-protein and protein-DNA/RNA interactions play a fundamental role in a variety of biological processes. Determining the complex structures of these interactions is valuable, in which molecular docking has played an important role. To automatically make use of the binding information from the PDB in docking, here we have presented HDOCK, a novel web server of our hybrid docking algorithm of template-based modeling and free docking, in which cases with misleading templates can be rescued by the free docking protocol. The server supports protein-protein and protein-DNA/RNA docking and accepts both sequence and structure inputs for proteins. The docking process is fast and consumes about 10-20 min for a…

• NN
  National Natural Science Foundation of China

  Award: 31670724
• HU
  Huazhong University of Science and Technology

  Award: 3004012104
• NK
  National Key Research and Development Program of China

  Awards: 2016YFC1305805, 2016YFC1305800