ATP as a biological hydrotrope
Max Planck Institute of Molecular Cell Biology and Genetics · University of Chicago
Abstract
Hydrotropes are small molecules that solubilize hydrophobic molecules in aqueous solutions. Typically, hydrotropes are amphiphilic molecules and differ from classical surfactants in that they have low cooperativity of aggregation and work at molar concentrations. Here, we show that adenosine triphosphate (ATP) has properties of a biological hydrotrope. It can both prevent the formation of and dissolve previously formed protein aggregates. This chemical property is manifested at physiological concentrations between 5 and 10 millimolar. Therefore, in addition to being an energy source for biological reactions, for which micromolar concentrations are sufficient, we propose that millimolar concentrations of ATP…
Citation impact
- FWCI
- 35.32
- Percentile
- 100%
- References
- 39
Authors
7- APAvinash PatelCorresponding
Max Planck Institute of Molecular Cell Biology and Genetics
- LMLiliana MalinovskaCorresponding
Max Planck Institute of Molecular Cell Biology and Genetics
- SSShambaditya Saha
Max Planck Institute of Molecular Cell Biology and Genetics
- JWJie Wang
Max Planck Institute of Molecular Cell Biology and Genetics
- SASimon Alberti
Max Planck Institute of Molecular Cell Biology and Genetics
Topics & keywords
- Adenosine triphosphate
- Solubility
- Chemistry
- Biochemistry
- Solubilization
- Biophysics
- Biology
- Organic chemistry