articleHepatologyMay 18, 2017HYBRID OA

Circular RNA circMTO1 acts as the sponge of microRNA‐9 to suppress hepatocellular carcinoma progression

DHDan HanJLJiangxue LiHWHuamin WangXSXiaoping SuJHJin Hou

Second Military Medical University · Zhejiang University · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Noncoding RNAs play important roles in cancer biology, providing potential targets for cancer intervention. As a new class of endogenous noncoding RNAs, circular RNAs (circRNAs) have been recently identified in cell development and function, and certain types of pathological responses, generally acting as a microRNA (miRNA) sponge to regulate gene expression. Identifying the deregulated circRNAs and their roles in cancer has attracted much attention. However, the expression profile and function of circRNAs in human hepatocellular carcinoma (HCC) remain to be investigated. Here, we analyzed the expression profile of human circRNAs in HCC tissues and identified circMTO1 (mitochondrial translation optimization 1…

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Topics & keywords

Topics
Keywords
  • Gene silencing
  • microRNA
  • Biology
  • Cancer research
  • Competing endogenous RNA
  • Circular RNA
  • Small interfering RNA
  • Long non-coding RNA
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