articleDiabetesMay 31, 2017BRONZE OA

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

RARobert A. ScottLJLaura J. ScottRMReedik MägiLMLetizia MarulloKJKyle J. Gaulton

MRC Epidemiology Unit · University of Michigan · +116 more institutions

PubMed
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Abstract

To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using the 1000 Genomes multiethnic reference panel. Promising association signals were followed up in additional data sets (of 14,545 or 7,397 T2D case and 38,994 or 71,604 control subjects). We identified 13 novel T2D-associated loci (P < 5 × 10−8), including variants near the GLP2R, GIP, and HLA-DQA1 genes. Our analysis brought the total number of independent T2D associations to 128 distinct signals at 113 loci. Despite substantially increased sample size and…

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Topics & keywords

Topics
Keywords
  • Genome-wide association study
  • Imputation (statistics)
  • Biology
  • Genetic association
  • Type 2 diabetes
  • Single-nucleotide polymorphism
  • Genetics
  • Haplotype
UN Sustainable Development Goals
  • Good health and well-being
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