reviewInternational ImmunologyMay 23, 2017BRONZE OA

Hyperferritinemia and inflammation

KFKate F. KernanJAJoseph A. Carcillo

University of Pittsburgh

PubMed
Indexed incrossrefpubmed

Abstract

Understanding of ferritin biology has traditionally centered on its role in iron storage and homeostasis, with low ferritin levels indicative of deficiency and high levels indicative of primary or secondary hemochromatosis. However, further work has shown that iron, redox biology and inflammation are inexorably linked. During infection, increased ferritin levels represent an important host defense mechanism that deprives bacterial growth of iron and protects immune cell function. It may also be protective, limiting the production of free radicals and mediating immunomodulation. Additionally, hyperferritinemia is a key acute-phase reactants, used by clinicians as an indication for therapeutic intervention,…

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624
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100%
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Authors

2

Topics & keywords

Topics
Keywords
  • Inflammation
  • Ferritin
  • Biomarker
  • Immunology
  • Mediator
  • Immune system
  • Medicine
  • Bystander effect
UN Sustainable Development Goals
  • Good health and well-being
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