articleScience Translational MedicineMay 31, 2017GREEN OA

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

QSQiaoqiao ShiSCSaba ChowdhuryRMRong MaKXKevin X. LeSHSoyon Hong

Brigham and Women's Hospital · Harvard University · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

KO mice, consistent with an altered microglial phenotype. C3 deficiency also protected APP/PS1 mice against age-dependent loss of synapses and neurons. Our study suggests that complement C3 or downstream complement activation fragments may play an important role in Aβ plaque pathology, glial responses to plaques, and neuronal dysfunction in the brains of APP/PS1 mice.

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Authors

8

Topics & keywords

Topics
Keywords
  • Neurodegeneration
  • Complement (music)
  • Complement system
  • Medicine
  • Immunology
  • Biology
  • Disease
  • Pathology
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