Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study

Schwalbe, Ed C.; Lindsey, Janet C.; Nakjang, Sirintra; Crosier, Stephen; Smith, Amanda; Hicks, Debbie; Rafiee, Gholamreza; Hill, Rebecca M.; Iliasova, Alice; Stone, T. J.; Pizer, Barry; Michalski, Antony; Joshi, Abhijit; Wharton, Stephen B.; Jacques, Thomas S.; Bailey, Simon; Williamson, Daniel; Clifford, Steven C.

doi:10.1016/s1470-2045(17)30243-7

articleThe Lancet OncologyMay 22, 2017HYBRID OA

Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study

ECEd C. Schwalbe JCJanet C. Lindsey SNSirintra Nakjang SCStephen Crosier ASAmanda Smith

Northumbria University · Newcastle University · +6 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

BackgroundInternational consensus recognises four medulloblastoma molecular subgroups: WNT (MBWNT), SHH (MBSHH), group 3 (MBGrp3), and group 4 (MBGrp4), each defined by their characteristic genome-wide transcriptomic and DNA methylomic profiles. These subgroups have distinct clinicopathological and molecular features, and underpin current disease subclassification and initial subgroup-directed therapies that are underway in clinical trials. However, substantial biological heterogeneity and differences in survival are apparent within each subgroup, which remain to be resolved. We aimed to investigate whether additional molecular subgroups exist within childhood medulloblastoma and whether these could be used to…

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Topics & keywords

Topics

Keywords

Medulloblastoma
Cohort
Outcome (game theory)
Medicine
Pediatrics
Oncology
Internal medicine
Pathology

UN Sustainable Development Goals

Good health and well-being

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