High drug-loading nanomedicines: progress, current status, and prospects

Drug molecules transformed into nanoparticles or endowed with nanostructures with or without the aid of carrier materials are referred to as "nanomedicines" and can overcome some inherent drawbacks of free drugs, such as poor water solubility, high drug dosage, and short drug half-life in vivo. However, most of the existing nanomedicines possess the drawback of low drug-loading (generally less than 10%) associated with more carrier materials. For intravenous administration, the extensive use of carrier materials might cause systemic toxicity and impose an extra burden of degradation, metabolism, and excretion of the materials for patients. Therefore, on the premise of guaranteeing therapeutic effect and…

• NN
  National Natural Science Foundation of China

  Awards: 81271686, 81228011, and 81471771, 81271686, 81471771, 81228011
• NK
  National Key Research and Development Program of China

  Award: 2016YFC0100701