Selected Copper‐Based Reactions for C−N, C−O, C−S, and C−C Bond Formation
Chinese Academy of Sciences · Shanghai Institute of Organic Chemistry
Abstract
Metal-catalyzed cross-coupling reactions belong to the most important transformations in organic synthesis. Copper catalysis has received great attention owing to the low toxicity and low cost of copper. However, traditional Ullmann-type couplings suffer from limited substrate scopes and harsh reaction conditions. The introduction of several bidentate ligands, such as amino acids, diamines, 1,3-diketones, and oxalic diamides, over the past two decades has totally changed this situation as these ligands enable the copper-catalyzed coupling of aryl halides and nucleophiles at both low reaction temperatures and catalyst loadings. The reaction scope has also been greatly expanded, rendering this copper-based…
Citation impact
- FWCI
- 28.26
- Percentile
- 100%
- References
- 303
Authors
5- SBSubhajit Bhunia
Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry
- GGGovind Goroba Pawar
Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry
- SVS. Vijay Kumar
Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry
- YJYongwen Jiang
Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry
- DMDawei MaCorresponding
Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry
Topics & keywords
- Chemistry
- Aryl
- Trifluoromethylation
- Nucleophile
- Copper
- Electrophile
- Catalysis
- Coupling reaction