Surface-Enhanced Raman Scattering Active Gold Nanoparticles with Enzyme-Mimicking Activities for Measuring Glucose and Lactate in Living Tissues

Gold nanoparticles (AuNPs) with simultaneous plasmonic and biocatalytic properties provide a promising approach to developing versatile bioassays. However, the combination of AuNPs' intrinsic enzyme-mimicking properties with their surface-enhanced Raman scattering (SERS) activities has yet to be explored. Here we designed a peroxidase-mimicking nanozyme by in situ growing AuNPs into a highly porous and thermally stable metal-organic framework called MIL-101. The obtained AuNPs@MIL-101 nanozymes acted as peroxidase mimics to oxidize Raman-inactive reporter leucomalachite green into the active malachite green (MG) with hydrogen peroxide and simultaneously as the SERS substrates to enhance the Raman signals of…

• NN
  National Natural Science Foundation of China

  Awards: 21550110189, 21405079, 11474147, 21405081, 81671751
• MO
  Ministry of Science and Technology of the People's Republic of China

  Awards: 2014DFE00200, 2015CB654901, 2015CB659400
• CP
  China Postdoctoral Science Foundation

  Awards: 2016M590437, 2015M581770
• GO
  Government of Jiangsu Province
• NS
  Natural Science Foundation of Jiangsu Province

  Awards: BK20160615, BK20151383
• SK
  State Key Laboratory of Analytical Chemistry for Life Sciences

  Award: SKLACLS1704
• PA
  Priority Academic Program Development of Jiangsu Higher Education Institutions