Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

Grossman, Nir; Bono, David; Dedic, Nina; Kodandaramaiah, Suhasa B.; Rudenko, Andrii; Suk, Ho‐Jun; Cassarà, Antonino M.; Neufeld, Esra; Kuster, Niels; Tsai, Li-Huei; Pascual‐Leone, Álvaro; Boyden, Edward S.

doi:10.1016/j.cell.2017.05.024

articleCellJun 1, 2017HYBRID OA

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

NGNir Grossman DBDavid Bono NDNina Dedic SBSuhasa B. Kodandaramaiah ARAndrii Rudenko

Beth Israel Deaconess Medical Center · McGovern Institute for Brain Research · +14 more institutions

PubMed

Indexed incrossrefdatacitepubmed

Abstract

We report a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, we can electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. We validated this temporal interference (TI) concept via modeling and physics experiments, and verified that neurons in the living mouse brain could follow the electric field envelope. We demonstrate the utility of TI stimulation by stimulating neurons in the hippocampus…

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991

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FWCI: 32.15
Percentile: 100%
References: 40

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Authors

12

Topics & keywords

Topics

Keywords

Neuroscience
Biology
Local field potential
Stimulation
Electric field
Hippocampus
Envelope (radar)
Interference (communication)

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