reviewJournal of Cellular BiochemistryJun 1, 2017Closed access

Tumor Necrosis Factor‐Alpha: Role in Development of Insulin Resistance and Pathogenesis of Type 2 Diabetes Mellitus

MSMuhammad Sajid Hamid AkashKRKanwal RehmanALAamira Liaqat

Government College University, Faisalabad · University of Agriculture Faisalabad

PubMed
Indexed incrossrefpubmed

Abstract

Pathogenesis of type 2 diabetes mellitus (T2DM) and development of insulin resistance are characterized by multi-stimuli factors notably glucolipotoxicity, generation of reactive oxygen species (ROS), epigenetic factors, activation of various transcriptional mediated pathways along with the augmented levels of various pro-inflammatory cytokines. Among the various pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-α) is one the most important pro-inflammatory mediator that is critically involved in the development of insulin resistance and pathogenesis of T2DM. TNF-α is mainly produced in adipocytes and/or peripheral tissues, and induces tissue-specific inflammation through the involvement of…

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686
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25.37
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100%
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3

Topics & keywords

Topics
Keywords
  • Insulin resistance
  • Tumor necrosis factor alpha
  • Pathogenesis
  • Inflammation
  • Type 2 Diabetes Mellitus
  • Proinflammatory cytokine
  • Insulin
  • Insulin receptor
UN Sustainable Development Goals
  • Good health and well-being
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