reviewMolecular AutismMay 22, 2017GOLD OA

Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia

GQGenotyping quality control and imputation of the 14 independent cohorts were performed by the PGC Statistical Analysis Group. Each dataset was processed separately. Experimental details are described in the Additional file
PubMed
Indexed incrossrefdoajpubmed

Abstract

BACKGROUND: Over the past decade genome-wide association studies (GWAS) have been applied to aid in the understanding of the biology of traits. The success of this approach is governed by the underlying effect sizes carried by the true risk variants and the corresponding statistical power to observe such effects given the study design and sample size under investigation. Previous ASD GWAS have identified genome-wide significant (GWS) risk loci; however, these studies were of only of low statistical power to identify GWS loci at the lower effect sizes (odds ratio (OR)

Citation impact

643
total citations
FWCI
64.70
Percentile
100%
References
87
Citations per year

Authors

1
  • GQ
    Genotyping quality control and imputation of the 14 independent cohorts were performed by the PGC Statistical Analysis Group. Each dataset was processed separately. Experimental details are described in the Additional fileCorresponding

Topics & keywords

Topics
Keywords
  • Schizophrenia spectrum
  • Genome-wide association study
  • Autism spectrum disorder
  • Autism
  • Schizophrenia (object-oriented programming)
  • Neuropsychology
  • Psychology
  • Psychiatry
No related works found for this paper.

Funding