articleNature CommunicationsJun 13, 2017GOLD OA

Cellular senescence drives age-dependent hepatic steatosis

MOMikołaj OgrodnikSMSatomi MiwaTTTamar TchkoniaDTDina TiniakosCWCaroline Wilson

Newcastle Hospitals - Campus for Ageing and Vitality · Newcastle University · +13 more institutions

PubMed
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Abstract

Abstract The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of proinflammatory cytokines and mitochondrial dysfunction. Senescent cells contribute to age-related tissue degeneration. Here we show that the accumulation of senescent cells promotes hepatic fat accumulation and steatosis. We report a close correlation between hepatic fat accumulation and markers of hepatocyte senescence. The elimination of senescent cells by suicide gene-meditated ablation of p16 Ink4a -expressing senescent cells in INK-ATTAC mice or by treatment with a combination of the senolytic drugs dasatinib and…

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Topics & keywords

Topics
Keywords
  • Steatosis
  • Senescence
  • Fatty liver
  • Hepatocyte
  • Biology
  • Proinflammatory cytokine
  • Mitochondrion
  • Cell biology
UN Sustainable Development Goals
  • Good health and well-being
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