Photoinduced decarboxylative borylation of carboxylic acids

-hydroxyphthalimide ester derivative of the carboxylic acid under visible light at room temperature in the presence of the diboron reagent bis(catecholato)diboron. A simple workup allows isolation of the pinacol boronic ester. Experimental evidence suggests that boryl radical intermediates are involved in the process. The methodology is illustrated by the transformation of primary, secondary, and tertiary alkyl carboxylic acids as well as a diverse range of natural-product carboxylic acids, thereby demonstrating its broad utility and functional group tolerance.

• EA
  Engineering and Physical Sciences Research Council

  Awards: EP/K03927X/1, EP/I038071/1, award309290, EP/I038071/1
• HE
  H2020 European Research Council

  Awards: award309292, 670668
• HM
  H2020 Marie Skłodowska-Curie Actions

  Awards: 652890, award309291