The fate and lifespan of human monocyte subsets in steady state and systemic inflammation
University of London · University College London · +6 more institutions
Abstract
In humans, the monocyte pool comprises three subsets (classical, intermediate, and nonclassical) that circulate in dynamic equilibrium. The kinetics underlying their generation, differentiation, and disappearance are critical to understanding both steady-state homeostasis and inflammatory responses. Here, using human in vivo deuterium labeling, we demonstrate that classical monocytes emerge first from marrow, after a postmitotic interval of 1.6 d, and circulate for a day. Subsequent labeling of intermediate and nonclassical monocytes is consistent with a model of sequential transition. Intermediate and nonclassical monocytes have longer circulating lifespans (∼4 and ∼7 d, respectively). In a human experimental…
Citation impact
- FWCI
- 34.20
- Percentile
- 100%
- References
- 64
Authors
12Topics & keywords
- Monocyte
- Homeostasis
- Inflammation
- Immunology
- Cell biology
- Bone marrow
- Biology
- Chemistry