reviewCold Spring Harbor Perspectives in BiologyJun 15, 2017BRONZE OA

Interleukin-6 Family Cytokines

SRStefan Rose‐John

Kiel University

PubMed
Indexed incrossrefpubmed

Abstract

The interleukin (IL)-6 family cytokines is a group of cytokines consisting of IL-6, IL-11, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), cardiotrophin 1 (CT-1), cardiotrophin-like cytokine (CLC), and IL-27. They are grouped into one family because the receptor complex of each cytokine contains two (IL-6 and IL-11) or one molecule (all others cytokines) of the signaling receptor subunit gp130. IL-6 family cytokines have overlapping but also distinct biologic activities and are involved among others in the regulation of the hepatic acute phase reaction, in B-cell stimulation, in the regulation of the balance between regulatory and effector T cells, in metabolic…

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Topics & keywords

Topics
Keywords
  • Biology
  • Immunology
  • Physiology
UN Sustainable Development Goals
  • Good health and well-being
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