Making muscle: skeletal myogenesis in vivo and in vitro
Brigham and Women's Hospital · Howard Hughes Medical Institute · +6 more institutions
Abstract
Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative properties results in debilitating musculoskeletal disorders. Understanding the mechanisms that drive skeletal muscle formation will not only help to unravel the molecular basis of skeletal muscle diseases, but also provide a roadmap for recapitulating skeletal myogenesis in vitro from pluripotent stem cells (PSCs). PSCs have become an important tool for probing developmental questions, while differentiated cell types allow the development of novel therapeutic strategies. In this Review, we provide a comprehensive overview of skeletal myogenesis from the earliest premyogenic progenitor stage to terminally…
Citation impact
- FWCI
- 26.01
- Percentile
- 100%
- References
- 354
Authors
2- JCJérome ChalCorresponding
Brigham and Women's Hospital, Howard Hughes Medical Institute, Harvard University, Harvard Stem Cell Institute
- OPOlivier Pourquié
Brigham and Women's Hospital, Centre National de la Recherche Scientifique, Howard Hughes Medical Institute, Harvard University, Inserm, Institut de génétique et de biologie moléculaire et cellulaire, Harvard Stem Cell Institute, Université de Strasbourg
Topics & keywords
- Myogenesis
- Biology
- Skeletal muscle
- Progenitor cell
- Cell biology
- Myocyte
- Induced pluripotent stem cell
- Progenitor