The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis

Functional status and chronic health status are important baseline characteristics of critically ill patients. The assessment of frailty on admission to the intensive care unit (ICU) may provide objective, prognostic information on baseline health. To determine the impact of frailty on the outcome of critically ill patients, we performed a systematic review and meta-analysis comparing clinical outcomes in frail and non-frail patients admitted to ICU. We searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, PubMed, CINAHL, and Clinicaltrials.gov. All study designs with the exception of narrative reviews, case reports, and editorials were included. Included studies assessed frailty in…

• P
  Pfizer
• S
  Sanofi
• DM
  Dalhousie Medical Research Foundation
• CC
  Consortium canadien en neurodégénérescence associée au vieillissement
• GO
  Government of Canada
• AS
  Alzheimer Society
• NS
  Nova Scotia Health Research Foundation
• DU
  Dalhousie University
• HL
  H. Lundbeck A/S
• CF
  Canadian Frailty Network
• PC
  Pfizer Canada
• CI
  Canadian Institutes of Health Research