DeepLoc: prediction of protein subcellular localization using deep learning

MOTIVATION: The prediction of eukaryotic protein subcellular localization is a well-studied topic in bioinformatics due to its relevance in proteomics research. Many machine learning methods have been successfully applied in this task, but in most of them, predictions rely on annotation of homologues from knowledge databases. For novel proteins where no annotated homologues exist, and for predicting the effects of sequence variants, it is desirable to have methods for predicting protein properties from sequence information only. RESULTS: Here, we present a prediction algorithm using deep neural networks to predict protein subcellular localization relying only on sequence information. At its core, the…

• N
  Nvidia
• EK
  Eberhard Karls Universität Tübingen
• NN
  Novo Nordisk
• SU
  Stockholms Universitet
• NN
  Novo Nordisk Fonden