Inverse electron demand Diels–Alder reactions in chemical biology
University of Cambridge · University of Lisbon · +1 more institution
Abstract
The emerging inverse electron demand Diels-Alder (IEDDA) reaction stands out from other bioorthogonal reactions by virtue of its unmatchable kinetics, excellent orthogonality and biocompatibility. With the recent discovery of novel dienophiles and optimal tetrazine coupling partners, attention has now been turned to the use of IEDDA approaches in basic biology, imaging and therapeutics. Here we review this bioorthogonal reaction and its promising applications for live cell and animal studies. We first discuss the key factors that contribute to the fast IEDDA kinetics and describe the most recent advances in the synthesis of tetrazine and dienophile coupling partners. Both coupling partners have been…
Citation impact
- FWCI
- 38.87
- Percentile
- 100%
- References
- 377
Authors
3- BLB. L. OliveiraCorresponding
University of Cambridge
- ZGZijian Guo
University of Cambridge
- GJGonçalo J. L. BernardesCorresponding
University of Lisbon, University of Cambridge, Instituto de Medicina Molecular João Lobo Antunes
Topics & keywords
- Alder
- Diels–Alder reaction
- Electron
- Chemistry
- Computational chemistry
- Physics
- Organic chemistry
- Biology