Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis
Federico II University Hospital · The University of Texas Southwestern Medical Center · +2 more institutions
Abstract
AIMS: Gut microbiota-derived metabolite trimethylamine-N-oxide (TMAO) is emerging as a new potentially important cause of increased cardiovascular risk. The purpose of this meta-analysis was to systematically estimate and quantify the association between TMAO plasma levels, mortality, and major adverse cardio and cerebrovascular events (MACCE). METHODS AND RESULTS: MEDLINE, ISI Web of Science, and SCOPUS databases were searched for ad hoc studies published up to April 2017. Associations between TMAO plasma levels, all-cause mortality (primary outcome) and MACCE (secondary outcome) were systematically addressed. A total of 17 clinical studies were included in the analytic synthesis, enrolling 26 167 subjects.…
Citation impact
- FWCI
- 15.81
- Percentile
- 100%
- References
- 51
Authors
9- GGGabriele G. SchiattarellaCorresponding
Federico II University Hospital, The University of Texas Southwestern Medical Center
- ASAnna Sannino
Federico II University Hospital, Baylor Jack and Jane Hamilton Heart and Vascular Hospital
- ETEvelina Toscano
Federico II University Hospital
- GGGiuseppe Giugliano
Federico II University Hospital
- GGGiuseppe Gargiulo
University Hospital of Bern, Federico II University Hospital
Topics & keywords
- Trimethylamine N-oxide
- Medicine
- Hazard ratio
- Internal medicine
- Meta-analysis
- Confidence interval
- Relative risk
- Incidence (geometry)
- Good health and well-being