Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels

See Mander et al. (doi:10.1093/awx174) for a scientific commentary on this article.Sleep deprivation increases amyloid-β, suggesting that chronically disrupted sleep may promote amyloid plaques and other downstream Alzheimer's disease pathologies including tauopathy or inflammation. To date, studies have not examined which aspect of sleep modulates amyloid-β or other Alzheimer's disease biomarkers. Seventeen healthy adults (age 35-65 years) without sleep disorders underwent 5-14 days of actigraphy, followed by slow wave activity disruption during polysomnogram, and cerebrospinal fluid collection the following morning for measurement of amyloid-β, tau, total protein, YKL-40, and hypocretin. Data were compared…

• HC
  Hope Center for Neurological Disorders
• AN
  Alzheimer Nederland
• NI
  National Institutes of Health

  Awards: K23-NS089922, UL1RR024992, K23-NS089922, P01NS074969, P01-AG03991, P01-NS074969, P01-AG026276, NS074969, AG03991, KL2-TR000450, P01NS074969, KL2-TR000450, UL1RR024992