Cell biology of spinal cord injury and repair
University of California, Los Angeles
Abstract
Spinal cord injury (SCI) lesions present diverse challenges for repair strategies. Anatomically complete injuries require restoration of neural connectivity across lesions. Anatomically incomplete injuries may benefit from augmentation of spontaneous circuit reorganization. Here, we review SCI cell biology, which varies considerably across three different lesion-related tissue compartments: (a) non-neural lesion core, (b) astrocyte scar border, and (c) surrounding spared but reactive neural tissue. After SCI, axon growth and circuit reorganization are determined by neuron-cell-autonomous mechanisms and by interactions among neurons, glia, and immune and other cells. These interactions are shaped by both the…
Citation impact
- FWCI
- 13.86
- Percentile
- 100%
- References
- 169
Authors
3Topics & keywords
- Lesion
- Spinal cord injury
- Astrocyte
- Neuroscience
- Spinal cord
- Axon
- Glial scar
- Biology