The whole-genome landscape of medulloblastoma subtypes

Northcott, Paul A.; Buchhalter, Ivo; Morrissy, A. Sorana; Hovestadt, Volker; Weischenfeldt, Joachim; Ehrenberger, Tobias; Gröbner, Susanne; Segura‐Wang, Maia; Zichner, Thomas; Rudneva, Vasilisa A.; Warnatz, Hans-Jörg; Sidiropoulos, Nikos; Phillips, Aaron H.; Schumacher, Steven E.; Kleinheinz, Kortine; Waszak, Sebastian M.; Erkek, Serap; Jones, David; Worst, Barbara C.; Kool, Marcel; Zapatka, Marc; Jäger, Natalie; Chávez, Lukas; Hutter, Barbara; Bieg, Matthias; Paramasivam, Nagarajan; Heinold, Michael C.; Gu, Zuguang; Ishaque, Naveed; Jäger-Schmidt, Christina; Imbusch, Charles D.; Jugold, Alke; Hübschmann, Daniel; Risch, Thomas S.; Amstislavskiy, Vyacheslav; Rodríguez-González, F. Germán; Weber, Ursula; Wolf, Stephan; Robinson, Giles; Zhou, Xin; Wu, Gang; Finkelstein, David; Liu, Yanling; Cavalli, Florence M.G.; Luu, Betty; Ramaswamy, Vijay; Wu, Xiaochong; Köster, Jan; Ryzhova, Marina; Cho, Yoon-Jae; Pomeroy, Scott L.; Herold‐Mende, Christel; Schuhmann, Martin U.; Ebinger, Martin; Liau, Linda M.; Mora, Jaume; McLendon, Roger E.; Jabado, Nada; Kumabe, Toshihiro; Chuah, Eric; Ma, Yussanne; Moore, Richard A.; Mungall, Andrew J.; Mungall, Karen; Thiessen, Nina; Tse, Kane; Wong, Tina; Jones, Steven J.M.; Witt, Olaf; Milde, Till; Deimling, Andreas von; Capper, David; Korshunov, Andrey; Yaspo, Marie-Laure; Kriwacki, Richard W.; Gajjar, Amar; Zhang, Jinghui; Beroukhim, Rameen; Fraenkel, Ernest; Korbel, Jan O.; Brors, Benedikt; Schlesner, Matthias; Eils, Roland; Marra, Marco A.; Pfister, Stefan M.; Taylor, Michael D.; Lichter, Peter

doi:10.1038/nature22973

articleNatureJul 1, 2017HYBRID OA

The whole-genome landscape of medulloblastoma subtypes

PAPaul A. Northcott IBIvo Buchhalter ASA. Sorana Morrissy VHVolker Hovestadt JWJoachim Weischenfeldt

St. Jude Children's Research Hospital · German Cancer Research Center · +24 more institutions

PubMed

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Abstract

Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose debilitating effects on the developing child, and highlight the need for molecularly targeted treatments with reduced toxicity. Previous studies have been unable to identify the full spectrum of driver genes and molecular processes that operate in medulloblastoma subgroups. Here we analyse the somatic landscape across 491 sequenced medulloblastoma samples and the molecular heterogeneity among 1,256 epigenetically analysed cases, and identify subgroup-specific driver alterations that include previously undiscovered actionable targets. Driver mutations were confidently assigned to most patients belonging to Group 3 and Group…

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Keywords

Medulloblastoma
Biology
Genome
Computational biology
Genomics
Gene
Genetics
Bioinformatics

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