articleJournal of Enzyme Inhibition and Medicinal ChemistryJan 1, 2017GOLD OA

Beta-lactamase database (BLDB) – structure and function

TNThierry NaasSOSaoussen OueslatiRARémy A. BonninMLMaria Laura DabosAJAgustín Jacinto Zavala

Assistance Publique – Hôpitaux de Paris · Bicêtre Hospital · +4 more institutions

PubMed
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Abstract

Beta-Lactamase Database (BLDB) is a comprehensive, manually curated public resource providing up-to-date structural and functional information focused on this superfamily of enzymes with a great impact on antibiotic resistance. All the enzymes reported and characterised in the literature are presented according to the class (A, B, C and D), family and subfamily to which they belong. All three-dimensional structures of β-lactamases present in the Protein Data Bank are also shown. The characterisation of representative mutants and hydrolytic profiles (kinetics) completes the picture and altogether these four elements constitute the essential foundation for a better understanding of the structure-function…

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677
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8

Topics & keywords

Topics
Keywords
  • Subfamily
  • Context (archaeology)
  • Database
  • Function (biology)
  • Biology
  • Computational biology
  • Computer science
  • Genetics
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