Diabetic retinopathy: current understanding, mechanisms, and treatment strategies

Diabetic retinopathy (DR) causes significant visual loss on a global scale. Treatments for the vision-threatening complications of diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) have greatly improved over the past decade. However, additional therapeutic options are needed that take into account pathology associated with vascular, glial, and neuronal components of the diabetic retina. Recent work indicates that diabetes markedly impacts the retinal neurovascular unit and its interdependent vascular, neuronal, glial, and immune cells. This knowledge is leading to identification of new targets and therapeutic strategies for preventing or reversing retinal neuronal dysfunction, vascular…

• ML
  Massachusetts Lions Eye Research Fund

  Award: 3-SRA-2014-264-M-R
• JH
  Johns Hopkins University
• RS
  Royal Society
• QU
  Queen's University Belfast
• SF
  Science Foundation Ireland
• QU
  Queen's University
• NI
  National Institutes of Health

  Awards: EY022383, EY022683
• MR
  Medical Research Council

  Award: MC_PC_16083
• NE
  National Eye Institute

  Awards: 3-SRA-2014-264-M-R, EY022683