APP mouse models for Alzheimer's disease preclinical studies

Abstract Animal models of human diseases that accurately recapitulate clinical pathology are indispensable for understanding molecular mechanisms and advancing preclinical studies. The Alzheimer's disease (AD) research community has historically used first‐generation transgenic (Tg) mouse models that overexpress proteins linked to familial AD (FAD), mutant amyloid precursor protein (APP), or APP and presenilin (PS). These mice exhibit AD pathology, but the overexpression paradigm may cause additional phenotypes unrelated to AD. Second‐generation mouse models contain humanized sequences and clinical mutations in the endogenous mouse App gene. These mice show Aβ accumulation without phenotypes related to…

• JA
  Japan Agency for Medical Research and Development
• MO
  Ministry of Education, Culture, Sports, Science and Technology

  Awards: 26290019, 15K19036
• SF
  Svenska Forskningsrådet Formas
• V
  Vetenskapsrådet
• BH
  Bertil Hållstens Forskningsstiftelse
• A
  Alzheimerfonden
• NI
  National Institutes of Health

  Awards: AG022560, AG030142, R01 AG030142
• UO
  University of California, San Francisco
• MR
  Medical Research Council

  Award: MC_PC_17116
• JS
  Japan Science and Technology Agency

  Award: JPMJPR1285
• R
  RIKEN
• PR
  Precursory Research for Embryonic Science and Technology