An Interlaboratory Evaluation of Drift Tube Ion Mobility–Mass Spectrometry Collision Cross Section Measurements

Collision cross section (CCS) measurements resulting from ion mobility–mass spectrometry (IM-MS) experiments provide a promising orthogonal dimension of structural information in MS-based analytical separations. As with any molecular identifier, interlaboratory standardization must precede broad range integration into analytical workflows. In this study, we present a reference drift tube ion mobility mass spectrometer (DTIM-MS) where improvements on the measurement accuracy of experimental parameters influencing IM separations provide standardized drift tube, nitrogen CCS values (DTCCSN2) for over 120 unique ion species with the lowest measurement uncertainty to date. The reproducibility of these DTCCSN2…

• UE
  U.S. Environmental Protection Agency

  Award: 83573601
• DA
  Defense Advanced Research Projects Agency

  Award: W911 NF-14-2-0022
• NI
  National Institute of General Medical Sciences

  Award: R01 GM092218
• NI
  National Institute of Environmental Health Sciences

  Award: R01 ES022190
• AR
  Army Research Office

  Award: W911 NF-14-2-0022