Micromotor-enabled active drug delivery for in vivo treatment of stomach infection

Advances in bioinspired design principles and nanomaterials have led to tremendous progress in autonomously moving synthetic nano/micromotors with diverse functionalities in different environments. However, a significant gap remains in moving nano/micromotors from test tubes to living organisms for treating diseases with high efficacy. Here we present the first, to our knowledge, in vivo therapeutic micromotors application for active drug delivery to treat gastric bacterial infection in a mouse model using clarithromycin as a model antibiotic and Helicobacter pylori infection as a model disease. The propulsion of drug-loaded magnesium micromotors in gastric media enables effective antibiotic delivery, leading…

• NI
  National Institutes of Health

  Awards: HDTRA1-14-1-0064, R01DK095168
• DT
  Defense Threat Reduction Agency

  Awards: HDTRA1-13-1-0002, HDTRA1, HDTRA1-14-1-0064
• JP
  Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Award: R01DK095168