Analysis of Plasma Epstein–Barr Virus DNA to Screen for Nasopharyngeal Cancer
Chinese University of Hong Kong · Prince of Wales Hospital · +2 more institutions
Abstract
Circulating cell-free Epstein-Barr virus (EBV) DNA is a biomarker for nasopharyngeal carcinoma. We conducted a prospective study to investigate whether EBV DNA in plasma samples would be useful to screen for early nasopharyngeal carcinoma in asymptomatic persons.
We analyzed EBV DNA in plasma specimens to screen participants who did not have symptoms of nasopharyngeal carcinoma. Participants with initially positive results were retested approximately 4 weeks later, and those with persistently positive EBV DNA in plasma underwent nasal endoscopic examination and magnetic resonance imaging (MRI).
Citation impact
- FWCI
- 52.71
- Percentile
- 100%
- References
- 35
Authors
18- KAK.C. Allen ChanCorresponding
Chinese University of Hong Kong, Prince of Wales Hospital, I.R.C.C.S. Oasi Maria SS
- JKJohn K. S. Woo
Chinese University of Hong Kong, Prince of Wales Hospital, I.R.C.C.S. Oasi Maria SS
- ADAnn D. King
Chinese University of Hong Kong, Prince of Wales Hospital, I.R.C.C.S. Oasi Maria SS
- BZBenny Zee
Chinese University of Hong Kong, Hong Kong Jockey Club, Prince of Wales Hospital, I.R.C.C.S. Oasi Maria SS
- WLW.K. Lam
Chinese University of Hong Kong, Prince of Wales Hospital, I.R.C.C.S. Oasi Maria SS
Topics & keywords
- Nasopharyngeal carcinoma
- Medicine
- Asymptomatic
- Internal medicine
- Hazard ratio
- Prospective cohort study
- Confidence interval
- Cancer
- Good health and well-being