CircHIPK3 sponges miR‐558 to suppress heparanase expression in bladder cancer cells
Union Hospital · Wuhan Union Hospital · +4 more institutions
Abstract
Increasing evidences suggest that circular RNAs (circRNAs) exert crucial functions in regulating gene expression. In this study, we perform RNA-seq and identify 6,154 distinct circRNAs from human bladder cancer and normal bladder tissues. We find that hundreds of circRNAs are significantly dysregulated in human bladder cancer tissues. We further show that circHIPK3, also named bladder cancer-related circular RNA-2 (BCRC-2), is significantly down-regulated in bladder cancer tissues and cell lines, and negatively correlates with bladder cancer grade, invasion as well as lymph node metastasis, respectively. Over-expression of circHIPK3 effectively inhibits migration, invasion, and angiogenesis of bladder cancer…
Citation impact
- FWCI
- 36.44
- Percentile
- 100%
- References
- 47
Authors
11- YLYawei LiCorresponding
Union Hospital, Wuhan Union Hospital, Huazhong University of Science and Technology
- FZFuxin Zheng
Union Hospital, Wuhan Union Hospital, Huazhong University of Science and Technology
- XXXingyuan Xiao
Union Hospital, Wuhan Union Hospital, Huazhong University of Science and Technology
- FXFei Xie
Union Hospital, Wuhan Union Hospital, Huazhong University of Science and Technology
- DTDan Tao
Wuhan University, Fifth Hospital In Wuhan
Topics & keywords
- Heparanase
- Cancer
- Chemistry
- Cancer research
- Bladder cancer
- Cancer cell
- Cell biology
- Molecular biology
- Good health and well-being