The worldwide incidence and prevalence of systemic lupus erythematosus: a systematic review of epidemiological studies

The aim was to review the worldwide incidence and prevalence of SLE and variation with age, sex, ethnicity and time.

A systematic search of MEDLINE and EMBASE search engines was carried out using Medical Subject Headings and keyword search terms for Systemic Lupus Erythematosus combined with incidence, prevalence and epidemiology in August 2013 and updated in September 2016. Author, journal, year of publication, country, region, case-finding method, study period, number of incident or prevalent cases, incidence (per 100 000 person-years) or prevalence (per 100 000 persons) and age, sex or ethnic group-specific incidence or prevalence were collected.