Pavlovian conditioning–induced hallucinations result from overweighting of perceptual priors
Yale University · Scuola Internazionale Superiore di Studi Avanzati · +5 more institutions
Abstract
Some people hear voices that others do not, but only some of those people seek treatment. Using a Pavlovian learning task, we induced conditioned hallucinations in four groups of people who differed orthogonally in their voice-hearing and treatment-seeking statuses. People who hear voices were significantly more susceptible to the effect. Using functional neuroimaging and computational modeling of perception, we identified processes that differentiated voice-hearers from non-voice-hearers and treatment-seekers from non-treatment-seekers and characterized a brain circuit that mediated the conditioned hallucinations. These data demonstrate the profound and sometimes pathological impact of top-down cognitive…
Citation impact
- FWCI
- 37.10
- Percentile
- 100%
- References
- 30
Authors
3Topics & keywords
- Hallucinating
- Stimulus (psychology)
- Psychology
- Perception
- Classical conditioning
- Neuroimaging
- Neuroscience
- Auditory hallucination
- Good health and well-being
Funding
- IMInternational Mental Health Research OrganizationAward: award308860
- NANational Alliance for Research on Schizophrenia and DepressionAward: award308859
- NINational Institutes of HealthAwards: award309038, UL1 TR000142
- NINational Institute of Mental HealthAwards: award309043, 5T32MH019961, 5R01MH067073-09, award309037