articleCell ReportsAug 1, 2017GOLD OA

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

YXYangchun XieSZShan ZhuXSXinxin SongXSXiaofang SunYFYong Fan

Central South University · University of Pittsburgh · +16 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Ferroptosis is a form of regulated cell death that may facilitate the selective elimination of tumor cells. The tumor suppressor p53 (TP53) has been demonstrated to promote ferroptosis via a transcription-dependent mechanism. Here, we show that TP53 limits erastin-induced ferroptosis by blocking dipeptidyl-peptidase-4 (DPP4) activity in a transcription-independent manner. Loss of TP53 prevents nuclear accumulation of DPP4 and thus facilitates plasma-membrane-associated DPP4-dependent lipid peroxidation, which finally results in ferroptosis. These findings reveal a direct molecular link between TP53 and DPP4 in the control of lipid metabolism and may provide a precision medicine strategy for the treatment of…

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933
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Authors

15

Topics & keywords

Topics
Keywords
  • Suppressor
  • Transcription factor
  • Cell biology
  • Chemistry
  • Transcription (linguistics)
  • Cancer research
  • Endogeny
  • Programmed cell death
UN Sustainable Development Goals
  • Good health and well-being
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