Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

Abstract Many drugs have progressed through preclinical and clinical trials and have been available – for years in some cases – before being recalled by the FDA for unanticipated toxicity in humans. One reason for such poor translation from drug candidate to successful use is a lack of model systems that accurately recapitulate normal tissue function of human organs and their response to drug compounds. Moreover, tissues in the body do not exist in isolation, but reside in a highly integrated and dynamically interactive environment, in which actions in one tissue can affect other downstream tissues. Few engineered model systems, including the growing variety of organoid and organ-on-a-chip platforms, have so…

• WF
  Wake Forest University

  Awards: NCI CCSG P30CA012197, P30CA012197
• DT
  Defense Threat Reduction Agency

  Award: N6601-13-C-2027
• NC
  National Cancer Institute

  Awards: NCI CCSG P30CA012197, P30CA012197, CCSG P30CA012197