Tumor-selective catalytic nanomedicine by nanocatalyst delivery
Chinese Academy of Sciences · Shanghai Institute of Ceramics · +2 more institutions
Abstract
Abstract Tumor cells metabolize in distinct pathways compared with most normal tissue cells. The resulting tumor microenvironment would provide characteristic physiochemical conditions for selective tumor modalities. Here we introduce a concept of sequential catalytic nanomedicine for efficient tumor therapy by designing and delivering biocompatible nanocatalysts into tumor sites. Natural glucose oxidase (GOD, enzyme catalyst) and ultrasmall Fe 3 O 4 nanoparticles (inorganic nanozyme, Fenton reaction catalyst) have been integrated into the large pore-sized and biodegradable dendritic silica nanoparticles to fabricate the sequential nanocatalyst. GOD in sequential nanocatalyst could effectively deplete glucose…
Citation impact
- FWCI
- 57.33
- Percentile
- 100%
- References
- 39
Authors
4- MHMinfeng HuoCorresponding
Chinese Academy of Sciences, Shanghai Institute of Ceramics, University of Chinese Academy of Sciences
- LWLiying Wang
Chinese Academy of Sciences, ShanghaiTech University, Shanghai Institute of Ceramics, University of Chinese Academy of Sciences
- YCYu Chen
Chinese Academy of Sciences, Shanghai Institute of Ceramics
- JSJianlin Shi
Chinese Academy of Sciences, Shanghai Institute of Ceramics
Topics & keywords
- Tumor microenvironment
- Nanomedicine
- Catalysis
- Nanomaterial-based catalyst
- Glucose oxidase
- Nanoparticle
- Chemistry
- Microvesicles
Funding
- NSNatural Science Foundation of ShanghaiAward: 13ZR1463500
- NNNational Natural Science Foundation of ChinaAwards: 51132009, 13ZR1463500, 2016YFA0203700, 51672303, 2015QNRC001
- NKNational Key Research and Development Program of ChinaAwards: 2015QNRC001, 2016YFA0203700, 51672303
- YIYouth Innovation Promotion AssociationAward: 2013169