articleAntimicrobial Agents and ChemotherapyAug 14, 2017BRONZE OA

Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection

RTRobert T. SchooleyBBBiswajit BiswasJJJason J. GillAHAdriana Hernandez-MoralesJLJacob Lancaster

University of California San Diego · Henry M. Jackson Foundation · +7 more institutions

PubMed
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Abstract

ABSTRACT Widespread antibiotic use in clinical medicine and the livestock industry has contributed to the global spread of multidrug-resistant (MDR) bacterial pathogens, including Acinetobacter baumannii . We report on a method used to produce a personalized bacteriophage-based therapeutic treatment for a 68-year-old diabetic patient with necrotizing pancreatitis complicated by an MDR A. baumannii infection. Despite multiple antibiotic courses and efforts at percutaneous drainage of a pancreatic pseudocyst, the patient deteriorated over a 4-month period. In the absence of effective antibiotics, two laboratories identified nine different bacteriophages with lytic activity for an A. baumannii isolate from the…

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Topics & keywords

Topics
Keywords
  • Acinetobacter baumannii
  • Lytic cycle
  • Antibiotics
  • Medicine
  • Bacteriophage
  • Phage therapy
  • Intensive care medicine
  • Acinetobacter
UN Sustainable Development Goals
  • Industry, innovation and infrastructure
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