Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems
Showa University · Tokyo Medical and Dental University · +3 more institutions
Abstract
The immune and skeletal systems share a variety of molecules, including cytokines, chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune cells under physiological and pathological conditions. Osteoimmunology was created as a new interdisciplinary field in large part to highlight the shared molecules and reciprocal interactions between the two systems in both heath and disease. Receptor activator of NF-κB ligand (RANKL) plays an essential role not only in the development of immune organs and bones, but also in autoimmune diseases affecting bone, thus effectively comprising the molecule that links the two systems. Here we review the function, gene regulation, and signal…
Citation impact
- FWCI
- 16.37
- Percentile
- 100%
- References
- 564
Authors
9- KOKazuo OkamotoCorresponding
Showa University, Tokyo Medical and Dental University, Japan Agency for Medical Research and Development, Japan Science and Technology Agency, The University of Tokyo
- TNTomoki Nakashima
Showa University, Tokyo Medical and Dental University, Japan Agency for Medical Research and Development, Japan Science and Technology Agency, The University of Tokyo
- MSMasahiro Shinohara
Showa University, Tokyo Medical and Dental University, Japan Agency for Medical Research and Development, Japan Science and Technology Agency, The University of Tokyo
- TNTakako Negishi‐Koga
Showa University, Tokyo Medical and Dental University, Japan Agency for Medical Research and Development, Japan Science and Technology Agency, The University of Tokyo
- NKNoriko Komatsu
Showa University, Tokyo Medical and Dental University, Japan Agency for Medical Research and Development, Japan Science and Technology Agency, The University of Tokyo
Topics & keywords
- Osteoimmunology
- Immune system
- RANKL
- Biology
- Immunology
- Chemokine
- Bone marrow
- Osteoclast