A pathology atlas of the human cancer transcriptome

Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. Using genome-scale metabolic models, we show that cancer patients have widespread metabolic heterogeneity, highlighting the need for precise and personalized medicine for…

• KO
  Knut och Alice Wallenbergs Stiftelse

  Award: award306785
• SF
  Science for Life Laboratory
• UM
  Uppsala Multidisciplinary Center for Advanced Computational Science