Glymphatic MRI in idiopathic normal pressure hydrocephalus
Oslo University Hospital · University of Oslo
Abstract
The glymphatic system has in previous studies been shown as fundamental to clearance of waste metabolites from the brain interstitial space, and is proposed to be instrumental in normal ageing and brain pathology such as Alzheimer's disease and brain trauma. Assessment of glymphatic function using magnetic resonance imaging with intrathecal contrast agent as a cerebrospinal fluid tracer has so far been limited to rodents. We aimed to image cerebrospinal fluid flow characteristics and glymphatic function in humans, and applied the methodology in a prospective study of 15 idiopathic normal pressure hydrocephalus patients (mean age 71.3 ± 8.1 years, three female and 12 male) and eight reference subjects (mean age…
Citation impact
- FWCI
- 21.03
- Percentile
- 100%
- References
- 55
Authors
3Topics & keywords
- Gadobutrol
- Glymphatic system
- Cerebrospinal fluid
- Magnetic resonance imaging
- Medicine
- Subarachnoid space
- Hydrocephalus
- Normal pressure hydrocephalus