STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4
Shanghai Cancer Institute · Renji Hospital · +4 more institutions
Abstract
Several of the thousands of human long noncoding RNAs (lncRNAs) have been functionally characterized, yet their potential involvement in hepatocellular carcinoma (HCC) remains poorly understood.
LncRNA-HOXD-AS1 was identified by microarray and validated by real-time PCR. The clinicopathological significance of HOXD-AS1 was analyzed by Kaplan-Meier method. Chromatin immunoprecipitation was conducted to examine the mechanism of HOXD-AS1 upregulation. The role of HOXD-AS1 in HCC cells was assessed both in vitro and in vivo. ceRNA function of HOXD-AS1 was evaluated by RNA immunoprecipitation and biotin-coupled miRNA pull down assays.
Citation impact
- FWCI
- 16.77
- Percentile
- 100%
- References
- 52
Authors
15- HWHui WangCorresponding
Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University, State Key Laboratory of Oncogene and Related Genes
- XHXisong Huo
State Key Laboratory of Oncogene and Related Genes, Shanghai Jiao Tong University, Renji Hospital, Shanghai Cancer Institute
- XYXin‐Rong Yang
Zhongshan Hospital, Fudan University
- JHJia He
Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University, State Key Laboratory of Oncogene and Related Genes
- LCLijun Cheng
Shanghai Jiao Tong University, Shanghai Cancer Institute, Renji Hospital, State Key Laboratory of Oncogene and Related Genes
Topics & keywords
- Competing endogenous RNA
- Biology
- Downregulation and upregulation
- Cancer research
- Gene knockdown
- Chromatin immunoprecipitation
- Metastasis
- SOX4
- Good health and well-being
Funding
- NSNatural Science Foundation of ShanghaiAward: 16ZR1434700
- NNNational Natural Science Foundation of ChinaAwards: 81301759, 81472676, 81402278, 81201626, 863 Program, 81530077, 81672839, 81421001
- SJShanghai Jiao Tong University
- BOBijzonder Onderzoeksfonds UGent
- SOSchool of Medicine, Shanghai Jiao Tong UniversityAward: YG2015QN34
- NHNational High-tech Research and Development ProgramAward: 2015AA020401
- NKNational Key Research and Development Program of ChinaAward: 2015CB553905