The Functional Impact of Alternative Splicing in Cancer
Inserm · Universitat Pompeu Fabra · +8 more institutions
Abstract
Alternative splicing changes are frequently observed in cancer and are starting to be recognized as important signatures for tumor progression and therapy. However, their functional impact and relevance to tumorigenesis remain mostly unknown. We carried out a systematic analysis to characterize the potential functional consequences of alternative splicing changes in thousands of tumor samples. This analysis revealed that a subset of alternative splicing changes affect protein domain families that are frequently mutated in tumors and potentially disrupt protein-protein interactions in cancer-related pathways. Moreover, there was a negative correlation between the number of these alternative splicing changes in…
Citation impact
- FWCI
- 27.70
- Percentile
- 100%
- References
- 62
Authors
4- HCHéctor Climente-González
Inserm, Universitat Pompeu Fabra, Université Paris Sciences et Lettres, École Nationale Supérieure des Mines de Paris, Institut Curie
- EPEduard Porta‐Pardo
Sanford Burnham Prebys Medical Discovery Institute, Discovery Institute, Barcelona Supercomputing Center, Universitat Politècnica de Catalunya
- AGAdam Godzik
Sanford Burnham Prebys Medical Discovery Institute, Discovery Institute
- EEEduardo EyrasCorresponding
Institució Catalana de Recerca i Estudis Avançats, Universitat Pompeu Fabra
Topics & keywords
- RNA splicing
- Alternative splicing
- Biology
- Carcinogenesis
- Computational biology
- Cancer
- Genetics
- Bioinformatics