Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease
University of Michigan · Michigan Center for Translational Pathology
Abstract
The intestinal tract of mammals is colonized by a large number of microorganisms including trillions of bacteria that are referred to collectively as the gut microbiota. These indigenous microorganisms have co-evolved with the host in a symbiotic relationship. In addition to metabolic benefits, symbiotic bacteria provide the host with several functions that promote immune homeostasis, immune responses, and protection against pathogen colonization. The ability of symbiotic bacteria to inhibit pathogen colonization is mediated via several mechanisms including direct killing, competition for limited nutrients, and enhancement of immune responses. Pathogens have evolved strategies to promote their replication in…
Citation impact
- FWCI
- 29.71
- Percentile
- 100%
- References
- 234
Authors
4- JMJoseph M. Pickard
University of Michigan, Michigan Center for Translational Pathology
- MYMelody Y. Zeng
University of Michigan, Michigan Center for Translational Pathology
- RCRoberta Caruso
University of Michigan, Michigan Center for Translational Pathology
- GNGabriel NúñezCorresponding
University of Michigan, Michigan Center for Translational Pathology
Topics & keywords
- Colonization
- Immune system
- Pathogen
- Biology
- Immunology
- Disease
- Inflammation
- Microbiology