Understanding the functions and relationships of the glymphatic system and meningeal lymphatics
University of Virginia · University of Rochester Medical Center · +2 more institutions
Abstract
Recent discoveries of the glymphatic system and of meningeal lymphatic vessels have generated a lot of excitement, along with some degree of skepticism. Here, we summarize the state of the field and point out the gaps of knowledge that should be filled through further research. We discuss the glymphatic system as a system that allows CNS perfusion by the cerebrospinal fluid (CSF) and interstitial fluid (ISF). We also describe the recently characterized meningeal lymphatic vessels and their role in drainage of the brain ISF, CSF, CNS-derived molecules, and immune cells from the CNS and meninges to the peripheral (CNS-draining) lymph nodes. We speculate on the relationship between the two systems and their…
Citation impact
- FWCI
- 24.74
- Percentile
- 100%
- References
- 109
Authors
6- ALAntoine Louveau
University of Virginia
- BABenjamin A. Plog
University of Rochester Medical Center
- SASalli Antila
University of Helsinki, Wihuri Research Institute
- KAKari AlitaloCorresponding
University of Helsinki, Wihuri Research Institute
- MNMaiken NedergaardCorresponding
University of Rochester Medical Center
Topics & keywords
- Glymphatic system
- Meninges
- Lymphatic system
- Interstitial fluid
- Cerebrospinal fluid
- Pathology
- Neuroscience
- Immune system