Bacteria antibiotic resistance: New challenges and opportunities for implant‐associated orthopedic infections

There has been a dramatic increase in the emergence of antibiotic-resistant bacterial strains, which has made antibiotic choices for infection control increasingly limited and more expensive. In the U.S. alone, antibiotic-resistant bacteria cause at least 2 million infections and 23,000 deaths a year resulting in a $55-70 billion per year economic impact. Antibiotics are critical to the success of surgical procedures including orthopedic prosthetic surgeries, and antibiotic resistance is occurring in nearly all bacteria that infect people, including the most common bacteria that cause orthopedic infections, such as Staphylococcus aureus (S. aureus). Most clinical cases of orthopedic surgeries have shown that…

• UD
  U.S. Department of Defense
• NA
  National Aeronautics and Space Administration
• OR
  Orthopaedic Research and Education Foundation
• OA
  Osteosynthesis and Trauma Care Foundation
• AF
  AO Foundation

  Award: S‐13‐15L
• NI
  National Institutes of Health

  Awards: GM103488, RR020866, GM104942, GM103434, GM103488/RR032138, RR032138, OD016165
• NO
  NIH Office of the Director

  Awards: GM103488/RR032138, OD016165, GM103434, GM104942, RR020866
• CD
  Congressionally Directed Medical Research Programs
• OO
  Office of Experimental Program to Stimulate Competitive Research